Etiology of Duchenne/Becker muscular dystrophy

This section provides information about the X-linked etiology of Duchenne and Becker muscular dystrophies. Duchenne and Becker occur when mutations in the dystrophin gene disrupt the production of normal levels of functional dystrophin protein. In general:

  • Duchenne muscular dystrophy is caused by mutations that prevent dystrophin expression, and
  • Becker muscular dystrophy is the result of mutations that cause reduced amounts of protein or structurally abnormal protein.