Characteristics of X-linked recessive inheritance

  • Males are primarily affected. Rarely, females may have symptoms, but carrier females are usually unaffected.
  • A son of a carrier mother has a 50% risk to inherit the mutation and thus have the disorder.
  • There is no male-to-male transmission of the disorder.
  • Affected males transmit the mutation to all daughters, who would be carriers, but not to any sons.

This image shows how X-linked mutations may be passed from a carrier mother to children.